Phenotypes Associated with This Genotype

Genotype
MGI:7413042

• Allelic Composition: Mirc30^em1Hhzg/Mirc30^em1Hhzg; Tg(Vav1-cre)#Cgp/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6NRj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased spleen weight ( J:320883 )

increased pro-B cell number ( J:320883 )

• increased percentage

increased B cell number ( J:320883 )

• increased CD5+ B cell in the blood of 10-month-old mice

increased pre-B cell number ( J:320883 )

• increased percentage

abnormal NK cell morphology ( J:320883 )

• partially block NK cell development at the stage III to stage IV transition

neoplasm

increased chronic lymphocytic leukemia incidence ( J:320883 )

growth/size/body

increased spleen weight ( J:320883 )

hematopoietic system

increased spleen weight ( J:320883 )

increased pro-B cell number ( J:320883 )

• increased percentage

increased B cell number ( J:320883 )

• increased CD5+ B cell in the blood of 10-month-old mice

increased pre-B cell number ( J:320883 )

• increased percentage

abnormal NK cell morphology ( J:320883 )

• partially block NK cell development at the stage III to stage IV transition

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:320883