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Phenotypes Associated with This Genotype
Genotype
MGI:7425030
cx3
Allelic
Composition		 Eme1Tn(pb-Act-RFP)1.1Zhu/Eme1+
Gen1Tn(pb-Act-RFP)1.1Zhu/Gen1Tn(pb-Act-RFP)1.1Zhu
Genetic
Background		 FVB/NJ-Eme1Tn(pb-Act-RFP)1.1Zhu Gen1Tn(pb-Act-RFP)1.1Zhu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eme1Tn(pb-Act-RFP)1.1Zhu mutation (0 available); any Eme1 mutation (43 available)
Gen1Tn(pb-Act-RFP)1.1Zhu mutation (0 available); any Gen1 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased cellular sensitivity to DNA damaging agents ( J:330453 )
• in mouse embryonic fibroblasts treated with camptothecin or etoposidecompared with cells from Eme1Tn(pb-Act-RFP)1.1Zhu heterozygotes
• however, cells treated with mitomycin C, methyl methanesulfonate, or hydroxy- urea exhibit normal survival

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory