Phenotypes Associated with This Genotype

Genotype
MGI:7437702

• Allelic Composition: Cwh43^em1Mdj/Cwh43^em1Mdj
• Genetic Background: C57BL/6-Cwh43^em1Mdj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:310176 )

• 7-month-old mice show decreased balance times on the rotarod

abnormal gait ( J:310176 )

• gait analysis shows increased rear leg sway at 7 months of age

nervous system

hydrocephaly ( J:310176 )

• mice appear normal at birth but develop hydrocephalus during middle age

abnormal brain ventricle morphology ( J:310176 )

• the distribution of GPI-anchored proteins in the ventricular ciliated epithelium is altered in middle-aged mice

abnormal brain ependyma morphology ( J:310176 )

• the number of microvilli on the ependymal surface is decreased in middle-aged mice

decreased brain ependyma motile cilium number ( J:310176 )

• the brain ventricular surface shows an approximate 28% decrease in the number of ependymal cilia at middle age

• however, obvious differences in cilia length are not seen

dilated brain ventricle ( J:310176 )

• ventricular volume is increased by about 18.3% in 6-month-old mice

• however, brains are grossly normal and the cerebral aqueduct is patent

cellular

decreased brain ependyma motile cilium number ( J:310176 )

• the brain ventricular surface shows an approximate 28% decrease in the number of ependymal cilia at middle age

• however, obvious differences in cilia length are not seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
normal pressure hydrocephalus		DOID:1572	OMIM:236690	J:310176