Phenotypes Associated with This Genotype

Genotype
MGI:7437706

• Allelic Composition: Cwh43^em1Mdj/Cwh43⁺
• Genetic Background: C57BL/6-Cwh43^em1Mdj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:310176 )

• 7-month-old mice show decreased balance times on the rotarod

nervous system

hydrocephaly ( J:310176 )

• mice appear normal at birth but develop hydrocephalus during middle age

abnormal brain ventricle morphology ( J:310176 )

• the distribution of GPI-anchored proteins in the ventricular ciliated epithelium is altered in middle aged mice

dilated brain ventricle ( J:310176 )

• ventricular volume is increased by about 24.2% in 6-month-old mice

• however, brains are grossly normal and the cerebral aqueduct is patent

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
normal pressure hydrocephalus		DOID:1572	OMIM:236690	J:310176