Analysis Tools
renal/urinary system
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• increased mesangial cell proliferation at 12 weeks of age
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|
• podocyte detachment at 12 weeks of age
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albuminuria
(
J:333727
)
|
• progressive albuminuria, starting at 6 weeks after birth
• however, no increase in proteinuria is detected at birth
|
|
• TEM analysis showed pronounced widening and misconfiguration (effacement) of podocyte foot processes at 8 and 12 weeks of age
• 3D SIM microscopy showed reduced filtration slit density (FSD), indicating aberrant foot process architecture at 8 weeks of age
• SEM revealed marked simplification, reduced branching, and misconfiguration of podocyte foot processes
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• marked rarefaction and loss of slit diaphragms at 12 weeks of age
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• progressive podocyte loss
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• mesangial sclerosis at 12 weeks of age
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• mice develop a nephrotic syndrome with a late-onset focal segmental glomerulosclerosis (FSGS)-like phenotype in adulthood
• a significantly increased glomerulosclerosis score is noted at 8 and 12 weeks of age
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• tubular dilation at 12 weeks of age
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renal cast
(
J:333727
)
|
• formation of proteinaceous casts at 12 weeks of age
|
|
• progressive loss of filtration-barrier function, starting at 6 weeks after birth
|
cellular
|
• increased mesangial cell proliferation at 12 weeks of age
|
|
• podocyte detachment at 12 weeks of age
|
homeostasis/metabolism
albuminuria
(
J:333727
)
|
• progressive albuminuria, starting at 6 weeks after birth
• however, no increase in proteinuria is detected at birth
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| focal segmental glomerulosclerosis | DOID:1312 |
OMIM:PS603278 |
J:333727 | |
