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Phenotypes Associated with This Genotype
Genotype
MGI:7444296
Allelic
Composition		 Mlxtm1.2Rne/Mlxtm1.2Rne
Genetic
Background		 involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlxtm1.2Rne mutation (0 available); any Mlx mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
teratozoospermia ( J:324060 )
• highly abnormal morphologies relative to controls including malformed heads and abnormal midpiece and tail structures
• epididymides contain populations of cells with an immature appearance
abnormal sperm progressive motility ( J:324060 )
• spermatozoa that reached the cauda epididymis in mutant animals exhibited a lack of progressive motility

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:324060 )
• abnormal and acellular

reproductive system
teratozoospermia ( J:324060 )
• highly abnormal morphologies relative to controls including malformed heads and abnormal midpiece and tail structures
• epididymides contain populations of cells with an immature appearance
abnormal sperm progressive motility ( J:324060 )
• spermatozoa that reached the cauda epididymis in mutant animals exhibited a lack of progressive motility
abnormal seminiferous tubule morphology ( J:324060 )
• abnormal and acellular

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
oligoasthenoteratozoospermia DOID:0070311 J:324060

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory