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Phenotypes Associated with This Genotype
Genotype
MGI:7467130
Allelic
Composition		 Ctnna1em1Xjz/Ctnna1tm1Efu
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
Genetic
Background		 involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6J * C57BL/6NCrl * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnna1em1Xjz mutation (0 available); any Ctnna1 mutation (133 available)
Ctnna1tm1Efu mutation (1 available); any Ctnna1 mutation (133 available)
Gt(ROSA)26Sortm14(CAG-tdTomato)Hze mutation (5 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Pdgfb-icre/ERT2,-EGFP)1Frut mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased angiogenesis ( J:328283 )
• slower growth of horizontal blood vessels in retina at age P7 after tamoxifen administration from age P1-P4
hemorrhage ( J:328283 )
• increased blood vessel leakage in retina at age P7 after tamoxifen administration from age P1-P4

vision/eye
abnormal retina development ( J:328283 )
• slower growth of horizontal blood vessels in retina at age P7 after tamoxifen administration from age P1-P4
• increased blood vessel leakage at age P7 after tamoxifen administration from age P1-P4

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
exudative vitreoretinopathy DOID:0050535 OMIM:PS133780
 J:328283

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory