Phenotypes Associated with This Genotype

Genotype
MGI:7467133

• Allelic Composition: Ctnnb1^em1V/Ctnnb1^em1V; Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased angiogenesis ( J:328283 )

• delayed superficial blood vessel growth and defects in vertical blood vessel growth in retina at age P9 after tamoxifen administration from age P1-P4

• absent secondary and tertiary blood vessels in deeper layers of retina at age P9 after tamoxifen administration from age P1-P4

• mild delay of blood vessel growth in deeper layers of retina at age P13 after tamoxifen administration from age P6

vision/eye

abnormal retina development ( J:328283 )

• delayed superficial blood vessel growth and defects in vertical blood vessel growth at age P9 after tamoxifen administration from age P1-P4

• absent secondary and tertiary blood vessels in deeper layers at age P9 after tamoxifen administration from age P1-P4

• mild delay of blood vessel growth in deeper layers at age P13 after tamoxifen administration from age P6

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
exudative vitreoretinopathy		DOID:0050535	OMIM:PS133780	J:328283