Phenotypes for Lrp5 MGI:7467137 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Lrp5^em1Xjz/Lrp5^em1Xjz
Genetic Background	C57BL/6J-Lrp5^em1Xjz

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Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp5^em1Xjz mutation (0 available); any Lrp5 mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased angiogenesis ( J:328283 )

• delayed superior blood vessel growth and defects in vertical blood vessel growth in retina at age P6

• absent secondary and tertiary blood vessels in deeper layers of retina at age P6

• delayed blood vessel growth in deeper layers of retina at age P13

vision/eye

abnormal retina development ( J:328283 )

• delayed superior blood vessel growth and defects in vertical blood vessel growth at age P6

• absent secondary and tertiary blood vessels in deeper layers at age P6

• delayed blood vessel growth in deeper layers at age P13

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
exudative vitreoretinopathy		DOID:0050535	OMIM:PS133780	J:328283

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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