Phenotypes Associated with This Genotype

Genotype
MGI:7488220

• Allelic Composition: St6galnac1^em1Len/St6galnac1^em1Len
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:324883 )

N • normal gross histology of gastro-intestinal tract

N • normal GCs, Paneth cells, tight junction markers and immune cells

decreased intestinal mucosa thickness ( J:324883 )

• reduced thickness of colon inner mucus layer

• increased microbial invasion of colon mucosa

abnormal large intestine morphology ( J:324883 )

• different and reduced diversity in fecal microbiome after weaning

abnormal colon morphology ( J:324883 )

• reduced thickness of inner mucus layer

increased susceptibility to colitis induced morbidity/mortality ( J:324883 )

• more severe phenotype from DSS-induced colitis, alleviated by oral lavage with mucin or administration of antibiotic cocktail prior to colitis induction

• reduced intestinal stem cell (ISC) proliferation after DSS-induced colitis, alleviated by administration of antibiotic cocktail prior to colitis induction

endocrine/exocrine glands

abnormal mucous gland physiology ( J:324883 )

• reduced mucin glycosylation in intestinal epidermal cells (IECs)

immune system

increased susceptibility to colitis induced morbidity/mortality ( J:324883 )

• more severe phenotype from DSS-induced colitis, alleviated by oral lavage with mucin or administration of antibiotic cocktail prior to colitis induction

• reduced intestinal stem cell (ISC) proliferation after DSS-induced colitis, alleviated by administration of antibiotic cocktail prior to colitis induction

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:324883 )

• more severe phenotype from DSS-induced colitis, alleviated by oral lavage with mucin or administration of antibiotic cocktail prior to colitis induction

• reduced intestinal stem cell (ISC) proliferation after DSS-induced colitis, alleviated by administration of antibiotic cocktail prior to colitis induction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:324883