Phenotypes Associated with This Genotype

Genotype
MGI:7511767

• Allelic Composition: Aicda^em1Jaych/Aicda^em1Jaych
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:305843 )

N • normal absolute number and frequency of developing and mature B cells in bone marrow and spleen

abnormal class switch recombination ( J:305843 )

• 10-1000x reduction in levels of class-switched antibodies

• no class-switched germinal center B cells in mesenteric lymph nodes or Peyers patches

• no class-switched germinal center B cells in mediastinal lymph nodes or spleen after infection with PR8 (mouse influenza A virus)

abnormal splenic cell ratio ( J:305843 )

• increased germinal center B cell frequency

• increased germinal center B cell frequency after infection with PR8 (mouse influenza A virus)

increased IgM level ( J:305843 )

• ~4x increase in serum

immune system

abnormal class switch recombination ( J:305843 )

• 10-1000x reduction in levels of class-switched antibodies

• no class-switched germinal center B cells in mesenteric lymph nodes or Peyers patches

• no class-switched germinal center B cells in mediastinal lymph nodes or spleen after infection with PR8 (mouse influenza A virus)

abnormal splenic cell ratio ( J:305843 )

• increased germinal center B cell frequency

• increased germinal center B cell frequency after infection with PR8 (mouse influenza A virus)

increased IgM level ( J:305843 )

• ~4x increase in serum

abnormal Peyer's patch germinal center morphology ( J:305843 )

• increased B cell frequency and absolute number

abnormal lymph node cell ratio ( J:305843 )

• increased germinal center B cell frequency in mesenteric lymph nodes

• increased germinal center B cell frequency in mediastinal lymph nodes after infection with PR8 (mouse influenza A virus)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
immunodeficiency with hyper-IgM type 2		DOID:0060758	OMIM:605258	J:305843