Phenotypes for Poc1b MGI:7530054 MGI Mouse

oligozoospermia ( J:340269 )

• sperm number is reduced by 98%

teratozoospermia ( J:340269 )

• the few sperm that are found are malformed; sperm deformities are heterogenous, with poorly formed heads, shorter midpieces, and truncated and infrequently forked tails, indicating oligoteratozoospermia

abnormal sperm flagellum morphology ( J:340269 )

• sperm exhibit flagella deformities

• infrequent forked tails

abnormal outer dense fiber morphology ( J:340269 )

• outer dense fibers are abnormally numbered and organized in most of the mid-pieces and principal pieces

absent sperm axonemal central pair ( J:340269 )

• missing or unorganized central-pair microtubules are seen in the primary piece

abnormal sperm end piece morphology ( J:340269 )

• absent end piece

abnormal sperm midpiece morphology ( J:340269 )

• shorter midpieces

short sperm flagellum ( J:340269 )

abnormal sperm head morphology ( J:340269 )

• poorly formed heads

• sperm heads from epididymis show bifurcation with dysmorphic chromatin and malformed acrosomes

abnormal acrosome morphology ( J:340269 )

• discrete-structure or irregularly shaped acrosome are seen in the cap and maturation phases of testes

abnormal spermatid morphology ( J:340269 )

• additional spermatocytes and spherical spermatids are detected, however the seminiferous tubules have a reduced number of elongated spermatids and missing mature spermatids

immotile sperm ( J:340269 )

• the few sperm that are found are immobile

male infertility ( J:340269 )

• males fail to produce any offspring in a fertility test

• however, mice show normal testis appearance and weight, and normal seminiferous tubule, Leydig, and Sertoli cell morphology