Phenotypes Associated with This Genotype

Genotype
MGI:7531415

• Allelic Composition: Nsf^tm1Himat/Nsf⁺
• Genetic Background: C57BL/6N-Nsf^tm1Himat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased anxiety-related response ( J:313900 )

• in the light/dark box test, mice exhibit a longer latency to enter the light box, indicting increased anxiety

increased vertical activity ( J:313900 )

• vertical activity is increased in the open-field test, indicating repetitive behavior

• however, no difference in the total distance traveled is seen in the open-field test

decreased social investigation ( J:313900 )

• in a three-chamber social interaction test, mice show less interaction with the stranger mouse during session 2 of the test

decreased vocalization ( J:313900 )

• at P6, pups emit fewer calls than wild-type pups

nervous system

abnormal postsynaptic density morphology ( J:313900 )

• mice show a decrease in postsynaptic density area in postsynaptic membrane of hippocampal -CA1 region

reduced long-term depression ( J:313900 )

• elevation of fEPSPs upon induction of long term depression (LTD) by low-frequency stimulation of Schaffer collaterals is deceased in hippocampal CA1 neurons

• however, no change in the fEPSPs is seen upon induction of long term potentiation (LTP) by high-frequency stimulation of Schaffer collaterals and no difference is seen in basal synaptic function

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:313900