Phenotypes Associated with This Genotype

Genotype
MGI:7537120

cn4

• Allelic Composition: Saraf^{tm1c(KOMP)Wtsi}/Saraf^{tm1c(KOMP)Wtsi}; Tg(Sim1-cre)1Lowl/0
• Genetic Background: involves: 129 * C57BL/6 * FVB
• Cell Lines: EPD0613_2_B07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

growth/size/body region phenotype ( J:337869 )

N • when fed a Western diet for 18 weeks, mice show no differences in total increase in body weight and composition relative to controls

increased lean body mass ( J:337869 )

• at 1 year, but not at 3 months, of age, percentage of lean mass is significantly higher than in control mice

decreased body weight ( J:337869 )

• at 1 year, but not at 3 months, of age, body weight is significantly lower than that in control mice

adipose tissue

adipose tissue phenotype ( J:337869 )

N • at 1 year of age, inguinal and visceral adipose tissues show no differences in WAT droplet size relative to control mice; lipid accumulation phenotype is unchanged in Western diet-fed mice

decreased brown adipose tissue amount ( J:337869 )

• at 1 year of age, intracapsular brown adipose tissue (iBAT) shows significantly less fat accumulation (pixels of fat droplets/area) than in control mice

decreased percent body fat/body weight ( J:337869 )

• at 1 year, but not at 3 months, of age, percentage of fat mass is significantly lower than in control mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:337869 )

N • at 3 months of age, mice exhibit normal glucose tolerance relative to control mice

N • when fed a Western diet for 18 weeks, mice show normal glucose tolerance and no differences in calorimetry relative to controls

increased basal metabolism ( J:337869 )

• at 1 year of age, mice exhibit increased heat production over time and a significant increase in heat production per body weight

liver/biliary system

liver/biliary system phenotype ( J:337869 )

N • mice show no fat accumulation in the liver at 1 year of age

behavior/neurological

behavior/neurological phenotype ( J:337869 )

• at 1 year of age, total food intake is not significantly altered, either under basal or refeed-challenged conditions; refeed responses are also unchanged in Western diet-fed mice

• at 3 months of age, mice do not exhibit altered anxiety-related behavioral phenotypes

increased locomotor activity ( J:337869 )

• at 3 months and at 1 year of age, mice exhibit increased dark-phase locomotion, as indicated by the light beam breaks count