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Phenotypes Associated with This Genotype
Genotype
MGI:7541130
Allelic
Composition
Wwoxem1Mald/Wwoxem1Mald
Genetic
Background
FVB/N-Wwoxem1Mald
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wwoxem1Mald mutation (0 available); any Wwox mutation (59 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• less time spent in center in open field test (OFT) and in open arms in elevated plus maze (EPM)
• less time spent investigating novel juvenile mouse and lack of preference for spending more time with novel mouse versus familiar mouse
• progressive age-related loss of motor capabilities to the point of immobility
• shorter latency to fall in rotarod test
• shorter distance traveled in open field test (OFT) and double latency to enter open arms in elevated plus maze (EPM)
• lack of preference for spending time with another mouse versus an empty cage
• spontaneous generalized convulsions
• generalized convulsions, beginning with sudden myoclonic jerk or jump, followed by whole-body rhythmic jerking movements

endocrine/exocrine glands
• in some mice

growth/size/body
N
• normal gross organ morphology
• in some mice

nervous system
• spontaneous generalized convulsions
• generalized convulsions, beginning with sudden myoclonic jerk or jump, followed by whole-body rhythmic jerking movements
• progressive age-related microgliosis in hippocampus
• in preculminate and primary fissures between cerebellar lobules III-VI
• in preculminate and primary fissures between cerebellar lobules III-VI
• fusion of interhemispheric fissure
• progressive age-related astrocytosis in hippocampus
• in corpus callosum
• normal number in parietal cortex

mortality/aging
• mean long-term survival of 393 days (vs 542 for WT)

hematopoietic system
• progressive age-related microgliosis in hippocampus

liver/biliary system
• in some mice
• focal liver degeneration in some mice
• in some mice

homeostasis/metabolism
N
• normal blood chemistry and hematological parameters

immune system
• progressive age-related microgliosis in hippocampus

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive spinocerebellar ataxia 12 DOID:0080060 OMIM:614322
J:339564


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory