Phenotypes Associated with This Genotype

Genotype
MGI:7545539

• Allelic Composition: Foxj1^{tm1.1(cre/ERT2/GFP)Htg}/Foxj1^{tm1.1(cre/ERT2/GFP)Htg}
• Genetic Background: STOCK Foxj1^{tm1.1(cre/ERT2/GFP)Htg}/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:342078 )

• the outflow tract may be positioned on the left, middle, right middle or left/middle in 58% of embryos

abnormal heart morphology ( J:342078 )

• all hearts show some abnormalities with most showing combined abnormalities

abnormal heart looping ( J:342078 )

• looping defects in 41.5% of embryos

• dextrocardia in 24.4%, combined ventral/sinistral looping in 4.9%, and absence of looping or single ventricles in 3.4%

abnormal heart and great vessel attachment ( J:342078 )

• in some embryos the positioning of aorta pulmonary trunk are abnormal

double outlet right ventricle ( J:342078 )

double inlet heart left ventricle ( J:342078 )

increased heart atrium size ( J:342078 )

abnormal heart position or orientation ( J:342078 )

• atrial isomerism and inverted atria

dextrocardia ( J:342078 )

• in 24.4% of embryos

atrioventricular septal defect ( J:342078 )

ventricular septal defect ( J:342078 )

• show various subtypes of defects including inlet, outlet, perimembranous, and muscular

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital heart disease		DOID:1682		J:342078