Phenotypes Associated with This Genotype

Genotype
MGI:7545550

• Allelic Composition: Lepr^db/Lepr^db
• Genetic Background: B6NTac.BKS(D)-Lepr^db

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased subcutaneous adipose tissue amount ( J:313303 )

increased body fat mass ( J:313303 )

increased white fat cell size ( J:313303 )

increased gonadal fat pad weight ( J:313303 )

behavior/neurological

increased food intake ( J:313303 )

abnormal locomotor circadian rhythm ( J:313303 )

• no activity, oxygen consumption and carbon dioxide production difference between light and dark periods

decreased locomotor activity ( J:313303 )

• constant low activity regardless of light or dark period

growth/size/body

increased body fat mass ( J:313303 )

obese ( J:313303 )

hematopoietic system

increased glycosylated hemoglobin level ( J:313303 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:313303 )

N • normal hepatic glycogen content

N • normal adiponectin serum concentrations

N • normal core body temperature in males

N • normal circulating post-fasting glucose levels in males

increased glycosylated hemoglobin level ( J:313303 )

increased fasting circulating glucose level ( J:313303 )

♀ • increased in females

increased circulating insulin level ( J:313303 )

• higher fasting serum insulin levels

increased circulating leptin level ( J:313303 )

increased circulating cholesterol level ( J:313303 )

increased circulating HDL cholesterol level ( J:313303 )

increased circulating LDL cholesterol level ( J:313303 )

increased circulating triglyceride level ( J:313303 )

decreased core body temperature ( J:313303 )

♀ • reduced in females

abnormal carbon dioxide production ( J:313303 )

• steady production regardless of light or dark period

abnormal oxygen consumption ( J:313303 )

• steady consumption regardless of light or dark period

impaired glucose tolerance ( J:313303 )

• higher glucose levels after glucose injection

increased liver triglyceride level ( J:313303 )

increased susceptibility to diet-induced non-insulin dependent diabetes ( J:313303 )

abnormal peptide metabolism ( J:313303 )

integument

increased subcutaneous adipose tissue amount ( J:313303 )

limbs/digits/tail

short tail ( J:313303 )

liver/biliary system

increased liver triglyceride level ( J:313303 )

increased susceptibility to diet-induced hepatic steatosis ( J:313303 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
obesity		DOID:9970	OMIM:601665	J:313303