Phenotypes Associated with This Genotype

Genotype
MGI:7545577

• Allelic Composition: Dll4^tm1Frad/Dll4⁺; Isl1^tm1(cre)Tmj/Isl1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:308916 )

• 9 of 28 embryos show outflow tract alignment defects

• however, septation of the outflow tract is preserved

double outlet right ventricle ( J:308916 )

• in embryos with a severe ventricular septal defect

overriding aortic valve ( J:308916 )

• in embryos with a shallower ventricular septal defect

ventricular septal defect ( J:308916 )

• some embryos show a prominent ventricular septal defect while in others this is more shallow

abnormal pulmonary valve morphology ( J:308916 )

• pulmonary valve arises more cranially and exits the right ventricle

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Adams-Oliver syndrome		DOID:0060227	OMIM:100300 OMIM:614219 OMIM:614814 OMIM:615297 OMIM:616028 OMIM:PS100300	J:308916