Phenotypes Associated with This Genotype

Genotype
MGI:7547388

• Allelic Composition: Rab39b^tm1Pdad/Y
• Genetic Background: B6N.Cg-Rab39b^tm1Pdad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired cued conditioning behavior ( J:341888 )

♂ • in trace fear conditioning, mice freeze less than wild-type mice during conditioning and in the consequent context and tone test sessions, indicating an inability to form associative memories

abnormal spatial working memory ( J:341888 )

♂ • mice show a slight impairment in working memory tasks in the 8-arm radial maze and the spontaneous alteration test, with mice showing decreased percentage of correct alternations in the spontaneous alternation task and a difference from wild-type mice in the correct arm choices before the first error over 10 days

♂ • however mice do not show differences in repetitive behaviors (grooming), anxiety-like behavior, motor coordination, explorative behaviors, or fear-related behaviors, and no differences in the water maze indicating intact spatial memory

decreased social investigation ( J:341888 )

♂ • 90-day-old males spend the same time sniffing a never-met mouse intruder and a novel object but are able to recognize a new never-met mouse intruder compared to the already known mouse in the three-chamber sociability test

nervous system

abnormal dendritic spine morphology ( J:341888 )

♂ • dendrite spine morphology shows an opposite ratio between mature and immature spines compared to wild-type, with an increase in filipodia-like mature dendritic spine structure and decrease in mushroom-like mature spines

increased dendritic spine density ( J:341888 )

♂ • 30-day-old brains show increased spine density

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
non-syndromic X-linked intellectual disability 72		DOID:0112059	OMIM:300271	J:341888