Phenotypes for Isl1 Jun MGI:7562004 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Jun^tm1Pa/Jun^tm4Wag Isl1^tm1(cre)Sev/Isl1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Sev mutation (1 available); any Isl1 mutation (36 available)
Jun^tm1Pa mutation (1 available); any Jun mutation (12 available)
Jun^tm4Wag mutation (0 available); any Jun mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:199412 )

• at E10.5, embryos show normal expression of Nfatc1 (an endocardial marker) relative to controls, suggesting normal endocardial formation

• a non-significant trend toward a decrease in proliferating pHH3+ cells and an increase in apoptotic TUNEL+ cells is noted in the cardiac outflow tract (OFT) at E10.5

embryo

embryo phenotype ( J:199412 )

N	• at E10.5, embryos show normal expression of Tfap2a during cardiac OFT development relative to controls, suggesting normal cardiac neural crest cell migration

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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