behavior/neurological
N |
• normal grip strength
• normal contextual and cued learning and memory
• no spontaneous seizures
|
• lower PTZ-induced seizure threshold and seizure latency
|
• more frequent entry into and more time spent in center of arena in open field test
• more time spent in light zone and more transitions between zones in light-dark test
|
• greater distance travelled in open field test and light-dark test
|
• seizures induced by handling
|
embryo
N |
• born at normal Mendelian ratios
|
growth/size/body
• lower body weight
|
hearing/vestibular/ear
N |
• normal auditory brainstem response (ABR) at age 14 weeks
|
homeostasis/metabolism
N |
• normal glucose tolerance and clinical blood biochemistry parameters
|
mortality/aging
N |
• viable
|
nervous system
N |
• normal prepulse inhibition (PPI)
|
• lower PTZ-induced seizure threshold and seizure latency
|
• seizures induced by handling
|