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Phenotypes Associated with This Genotype
Genotype
MGI:7567701
Allelic
Composition
Atp6v1b2em1Pcamp/Atp6v1b2em1Pcamp
Genetic
Background
C57BL/6N-Atp6v1b2em1Pcamp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp6v1b2em1Pcamp mutation (0 available); any Atp6v1b2 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• normal grip strength
• normal contextual and cued learning and memory
• no spontaneous seizures
• lower PTZ-induced seizure threshold and seizure latency
• more frequent entry into and more time spent in center of arena in open field test
• more time spent in light zone and more transitions between zones in light-dark test
• greater distance travelled in open field test and light-dark test
• seizures induced by handling

embryo
N
• born at normal Mendelian ratios

growth/size/body
• lower body weight

hearing/vestibular/ear
N
• normal auditory brainstem response (ABR) at age 14 weeks

homeostasis/metabolism
N
• normal glucose tolerance and clinical blood biochemistry parameters

mortality/aging
N
• viable

nervous system
N
• normal prepulse inhibition (PPI)
• lower PTZ-induced seizure threshold and seizure latency
• seizures induced by handling

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
epilepsy DOID:1826 J:342781


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory