Phenotypes Associated with This Genotype

Genotype
MGI:7571495

• Allelic Composition: Wfs1^tm1Koks/Wfs1^tm1Koks
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal inner hair cell stereociliary bundle morphology ( J:342760 )

• at age 10 months

cochlear outer hair cell degeneration ( J:342760 )

• at age 10 months

increased or absent threshold for auditory brainstem response ( J:342760 )

• higher ABR threshold at frequencies up to 10 kHz at age 4 months and all frequencies at age 10 months

impaired hearing ( J:342760 )

• higher auditory brainstem response (ABR) threshold at frequencies up to 10 kHz at age 4 months and all frequencies at age 10 months

nervous system

abnormal inner hair cell stereociliary bundle morphology ( J:342760 )

• at age 10 months

cochlear outer hair cell degeneration ( J:342760 )

• at age 10 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nonsyndromic deafness		DOID:0050563		J:342760