Phenotypes Associated with This Genotype

Genotype
MGI:7577436

• Allelic Composition: Crx^em1Smgc/Crx⁺
• Genetic Background: C57BL/6J-Crx^em1Smgc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

vision/eye phenotype ( J:343281 )

N • relatively normal retina INL, IPL and GCL

N • retina OS present

abnormal retina progenitor cell morphology ( J:343281 )

• premature rhodopsin expression in the outer part of retinal ONBL (outer neuroblast layer) layer at P3

disorganized retina outer nuclear layer ( J:343281 )

• waves, whorls and rosettes at age P21

decreased a-wave amplitude ( J:343281 )

• reduced dark-adapted ERG A-wave amplitude in response to light stimuli at age 1 month

decreased b-wave amplitude ( J:343281 )

• reduced dark-adapted ERG B-wave amplitude in response to light stimuli at age 1 month

abnormal cone electrophysiology ( J:343281 )

• no light-adapted B-wave ERG responses to light stimuli at age 1 month

abnormal rod electrophysiology ( J:343281 )

• reduced dark-adapted ERG A- and B-wave amplitudes in response to light stimuli at age 1 month

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cone-rod dystrophy 2		DOID:0111005	OMIM:120970	J:343281