Phenotypes Associated with This Genotype

Genotype
MGI:7578779

• Allelic Composition: Myl3^{tm1a(EUCOMM)Hmgu}/Myl3^{tm1a(EUCOMM)Hmgu}; Tg(Col2a1-cre)1Xya/0
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: HEPD0622_5_G02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

osteoarthritis ( J:343166 )

• 6-month-old mice exhibit cartilage destruction which becomes severe at 18 months of age indicating spontaneous age-related osteoarthritis

• cartilage destruction is accompanied by aggravated synovial inflammation but comparable osteophyte maturity as in controls

• expression of senescence, DNA damage, and catabolic markers are decreased in cartilage of aged mice

• however, mice exhibit normal skeletal development, with normal organization of growth plates and normal body weight

skeleton

osteoarthritis ( J:343166 )

• 6-month-old mice exhibit cartilage destruction which becomes severe at 18 months of age indicating spontaneous age-related osteoarthritis

• cartilage destruction is accompanied by aggravated synovial inflammation but comparable osteophyte maturity as in controls

• expression of senescence, DNA damage, and catabolic markers are decreased in cartilage of aged mice

• however, mice exhibit normal skeletal development, with normal organization of growth plates and normal body weight

abnormal chondrocyte physiology ( J:343166 )

• marker analysis indicates enhanced cellular senescence of chondrocytes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
osteoarthritis		DOID:8398		J:343166