Phenotypes Associated with This Genotype

Genotype
MGI:7579309

cx2

• Allelic Composition: Chchd10^em3Dpn/Chchd10^em3Dpn; Oma1^tm1Otin/Oma1^tm1Otin
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:344465 )

• neonatal lethality with few mice surviving to weaning

postnatal lethality, incomplete penetrance ( J:344465 )

• most pups die between P5 and P8, with the few survivors dying by 15 weeks of age

growth/size/body

enlarged heart ( J:344465 )

• mice that survive to 15 weeks of age have enlarged hearts

decreased body size ( J:344465 )

• mice that survive to 15 weeks of age exhibit decreased body size

decreased body weight ( J:344465 )

• body weight is lower at P5 but not at P1

cardiovascular system

enlarged heart ( J:344465 )

• mice that survive to 15 weeks of age have enlarged hearts

cellular

abnormal mitochondrial crista morphology ( J:344465 )

• heart mitochondria exhibit inclusions

abnormal mitochondrial shape ( J:344465 )

• surviving mice exhibit heart mitochondria that are longer but tend to have decreased caliber and thus smaller in volume

dilated mitochondrion ( J:344465 )

• megamitochondria, massively swollen mitochondria with lighter matrix density, are seen in hearts of 14-week-old mice