Phenotypes Associated with This Genotype

Genotype
MGI:7579310

cx3

• Allelic Composition: Chchd10^em3Dpn/Chchd10^em3Dpn; Oma1^tm1Otin/Oma1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle fiber mitochondrial morphology ( J:344465 )

• hearts show mitochondrial fragmentation, megamitochondria, and inclusions due to reshaping of the inner membrane

cellular

abnormal mitochondrial morphology ( J:344465 )

• mice exhibit smaller heart mitochondria, reflecting mitochondrial fragmentation

abnormal mitochondrial crista morphology ( J:344465 )

• heart mitochondria exhibit inclusions due to reshaping of the inner membrane

abnormal muscle fiber mitochondrial morphology ( J:344465 )

• hearts show mitochondrial fragmentation, megamitochondria, and inclusions due to reshaping of the inner membrane

dilated mitochondrion ( J:344465 )

• megamitochondria, massively swollen mitochondria with lighter matrix density, are seen in hearts of 14-week-old mice