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Phenotypes Associated with This Genotype
Genotype
MGI:7596101
Allelic
Composition		 Nudt15em1Maska/Nudt15+
Genetic
Background		 C57BL/6-Nudt15em1Maska
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nudt15em1Maska mutation (0 available); any Nudt15 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased neutrophil cell number ( J:285800 )
• after 14 days of 1 or 2 mg/kg mercaptopurine (MP) administration
pancytopenia ( J:285800 )
• after 14 days of 1 or 2 mg/kg mercaptopurine (MP) administration

immune system
decreased neutrophil cell number ( J:285800 )
• after 14 days of 1 or 2 mg/kg mercaptopurine (MP) administration

mortality/aging
premature death ( J:285800 )
• median lifespan of 48-66 days or 30 days after 1 or 2 mg/kg mercaptopurine (MP) administration, respectively
• minimum 70 day survival after 0.2 mg/kg mercaptopurine (MP) administration

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
leukopenia DOID:615 J:285800
neutropenia DOID:1227 J:285800
pancytopenia DOID:12450 J:285800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory