Phenotypes Associated with This Genotype

Genotype
MGI:7608060

cx2

• Allelic Composition: Lamp5^em1Lmit/Lamp5^em1Lmit; Tg(Thy1-APP)3Somm/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:345459 )

• mice exhibit earlier and more rapid mortality and poor overall survival compared to single Tg(Thy1-APP)3Somm hemizygotes

behavior/neurological

hyperactivity ( J:345459 )

• mice show increased hyperactivity over the entire test period compared to single Tg(Thy1-APP)3Somm hemizygotes

• memory could not be tested due to high premature mortality rate

nervous system

abnormal brain wave pattern ( J:345459 )

• hippocampal EEG recordings show a further increase in spontaneous discharges and spike trains than seen in single Tg(Thy1-APP)3Somm hemizygotes

• spectral power at gamma (30-100 Hz) frequency is increased more than in single Tg(Thy1-APP)3Somm hemizygotes or Lamp5^em1Lmit/Lamp5⁺ Tg(Thy1-APP)3Somm/0 mice, indicating neuronal network hypersynchronicity

• theta/gamma cross frequency coupling, an EEG measure linked to memory, is disrupted more than in single Tg(Thy1-APP)3Somm hemizygotes