Analysis Tools
hearing/vestibular/ear
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• decreased number of BK channels
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• mitochondria are concentrated in the center of the cytoplasm rather than along the plasma membrane, under the cuticular plate, and around the nucleus as in controls
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• massive outer hair cell loss from the apical region at P40
• however, inner hair cells, spiral ganglion and stria vascularis appear similar to controls
• outer hair cell loss begins by P30 and continues with age with near absence by P80
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• outer hair cell loss begins by P30 and continues with age with near absence by P80
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• at P40, show low-frequency but not high-frequency hearing loss
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cellular
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• mitochondria are concentrated in the center of the cytoplasm rather than along the plasma membrane, under the cuticular plate, and around the nucleus as in controls
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nervous system
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• decreased number of BK channels
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• mitochondria are concentrated in the center of the cytoplasm rather than along the plasma membrane, under the cuticular plate, and around the nucleus as in controls
|
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• massive outer hair cell loss from the apical region at P40
• however, inner hair cells, spiral ganglion and stria vascularis appear similar to controls
• outer hair cell loss begins by P30 and continues with age with near absence by P80
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• outer hair cell loss begins by P30 and continues with age with near absence by P80
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| nonsyndromic deafness | DOID:0050563 | J:345577 | ||
