Phenotypes Associated with This Genotype

Genotype
MGI:7618283

• Allelic Composition: Tubg1^tm1.1Ics/Tubg1⁺
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:275532 )

N • normal digging and grooming behavior

N • normal behavior in Y-maze test

increased susceptibility to pharmacologically induced seizures ( J:275532 )

• increased sensitivity to PTZ-induced tonic-clonic seizures

impaired contextual conditioning behavior ( J:275532 )

impaired cued conditioning behavior ( J:275532 )

abnormal response to novel object ( J:275532 )

• no preference for novel object

increased vertical activity ( J:275532 )

• increased rearing frequency in novel home cage

increased locomotor activity ( J:275532 )

• increased distance traveled in open field test

• increased rearing frequency and increased distance traveled during repetitive behavior in novel home cage

nervous system

nervous system phenotype ( J:275532 )

♂N • normal number and distribution of interneurons in brain at age 16 weeks

increased susceptibility to pharmacologically induced seizures ( J:275532 )

• increased sensitivity to PTZ-induced tonic-clonic seizures

decreased brain size ( J:275532 )

♂ • at age 16 weeks

abnormal brain white matter morphology ( J:275532 )

♂ • reduced white matter structures in anterior commissure and hippocampal fimbria at age 16 weeks

abnormal anterior commissure morphology ( J:275532 )

♂ • reduced white matter structures at age 16 weeks

abnormal hippocampus CA1 region morphology ( J:275532 )

♂ • heterotopic neurons (differentiated hippocampal pyramid neurons) in stratum oriens region positioned above pyramidal layer at age 16 weeks

decreased cerebral cortex total cell area ( J:275532 )

♂ • thinner cortex at age 16 weeks

decreased premotor cortex size ( J:275532 )

♂ • 9% thinner cortex and 10% less cross-sectional area at age 16 weeks

abnormal stratification in cerebral cortex ( J:275532 )

♂ • undetermined boundaries between layers II-III and V in some mice at age 16 weeks

thin cerebral cortex ( J:275532 )

♂ • at age 16 weeks

♂ • 23% less width of layer I and 20% less width of layer VI at age 16 weeks

small cerebellum ( J:275532 )

♂ • 27% smaller at age 16 weeks

growth/size/body

microcephaly ( J:275532 )

♂ • at age 16 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
complex cortical dysplasia with other brain malformations 4		DOID:0090138	OMIM:615412	J:342743