Analysis Tools
growth/size/body
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• heart weight is significantly increased both at 2 and at 10 weeks of age
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• body weight is significantly increased at 10 weeks of age
• all major organ weights analyzed, except liver weight, are significantly increased at 10 weeks of age
• increase in organ mass is proportional to the increase in overall body mass, suggesting a uniform overgrowth in multiple tissues
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• overall body length is significantly increased both at 2 and at 10 weeks of age
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• kidney weight is significantly increased at 10 but not at 2 weeks of age
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• lung weight is significantly increased both at 2 and at 10 weeks of age
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• liver weight is significantly increased at 2 but not at 10 weeks of age
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• spleen weight is significantly increased at 10 but not at 2 weeks of age
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skeleton
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• rate of proliferation is significantly increased in the proliferative zone of the proximal tibial growth plate at 2 weeks of age, as assessed by EdU incorporation
• although an overall increase in EdU+ resting chondrocytes is observed, the resting zone proliferative index (EdU count normalized to total cell number) is not significantly changed
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long tibia
(
J:347154
)
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• tibial bone length is significantly increased both at 2 and at 10 weeks of age
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• overall proximal tibia growth plate height is significantly increased at 2 weeks of age, along with a marked increase in the height of the resting zone
• however, the height of the proliferative zone and hypertrophic zone, number of proliferative and hypertrophic cells per column, and height of individual proliferative and terminal hypertrophic cells are not significantly changed
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• number of chondrocytes per 500 um growth plate width as well as the number of Sfrp5+ and CD73+ stem-like progenitor chondrocytes are significantly increased in the resting zone of the proximal tibial growth plate at 2 weeks of age
• when resting zone chondrocyte number is normalized to total area, the cell density is decreased, suggesting increased production or reduced resorption of cartilage extracellular matrix
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renal/urinary system
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• kidney weight is significantly increased at 10 but not at 2 weeks of age
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cardiovascular system
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• heart weight is significantly increased both at 2 and at 10 weeks of age
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respiratory system
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• lung weight is significantly increased both at 2 and at 10 weeks of age
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nervous system
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• brain weight is significantly increased both at 2 and at 10 weeks of age
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hematopoietic system
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• spleen weight is significantly increased at 10 but not at 2 weeks of age
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liver/biliary system
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• liver weight is significantly increased at 2 but not at 10 weeks of age
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limbs/digits/tail
long tibia
(
J:347154
)
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• tibial bone length is significantly increased both at 2 and at 10 weeks of age
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immune system
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• spleen weight is significantly increased at 10 but not at 2 weeks of age
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cellular
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• rate of proliferation is significantly increased in the proliferative zone of the proximal tibial growth plate at 2 weeks of age, as assessed by EdU incorporation
• although an overall increase in EdU+ resting chondrocytes is observed, the resting zone proliferative index (EdU count normalized to total cell number) is not significantly changed
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