Phenotypes Associated with This Genotype

Genotype
MGI:7638773

• Allelic Composition: Cylc1^em1Chnsr/Y
• Genetic Background: involves: C57BL/6JGpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:347872 )

♂N • testis size and weight is similar to controls

♂N • sperm count and total motility are similar to controls

abnormal sperm head morphology ( J:347872 )

♂ • display varying degrees of 'fan-shaped' heads

detached acrosome ( J:347872 )

♂ • varying degrees of detachment from the nuclear envelope in spermatids and sperm

♂ • enlarged space between the inner acrosomal membrane and the nuclear envelope in spermatids

reduced male fertility ( J:347872 )

♂ • severe male subfertility

impaired acrosome reaction ( J:347872 )

♂ • significant reduction in the calcium ionophore induced acrosome reaction rate

decreased fertilization frequency ( J:347872 )

♂ • in vitro fertilization using sperm from mutant mice produced a significantly lower percentage of two-cell embryos compared to sperm from wild-type mice

♂ • impaired fertilization can be rescued using intracytoplasmic sperm injection

cellular

abnormal sperm head morphology ( J:347872 )

♂ • display varying degrees of 'fan-shaped' heads

detached acrosome ( J:347872 )

♂ • varying degrees of detachment from the nuclear envelope in spermatids and sperm

♂ • enlarged space between the inner acrosomal membrane and the nuclear envelope in spermatids

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
male infertility		DOID:12336		J:347872