Phenotypes Associated with This Genotype

Genotype
MGI:7638774

• Allelic Composition: Cylc1^em2Chnsr/Y
• Genetic Background: involves: C57BL/6JGpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:347872 )

♂ • testis size and weight is similar to controls

♂ • sperm count and total motility are similar to controls

abnormal sperm head morphology ( J:347872 )

♂ • display varying degrees of 'fan-shaped' heads

♂ • F-actin bundles are show an uneven, thin, or ectopic F-actin distribution

detached acrosome ( J:347872 )

♂ • varying degrees of detachment from the nuclear envelope in spermatids and sperm

♂ • enlarged space between the inner acrosomal membrane and the nuclear envelope in spermatids

reduced male fertility ( J:347872 )

♂ • severe male subfertility

cellular

abnormal sperm head morphology ( J:347872 )

♂ • display varying degrees of 'fan-shaped' heads

♂ • F-actin bundles are show an uneven, thin, or ectopic F-actin distribution

detached acrosome ( J:347872 )

♂ • varying degrees of detachment from the nuclear envelope in spermatids and sperm

♂ • enlarged space between the inner acrosomal membrane and the nuclear envelope in spermatids

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
male infertility		DOID:12336		J:347872