Phenotypes Associated with This Genotype

Genotype
MGI:7640216

• Allelic Composition: Crx^rd23/Crx^rd23
• Genetic Background: B6.Cg-Crx^rd23/BocJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina blood vessel morphology ( J:348234 )

thin retina outer nuclear layer ( J:348234 )

retina outer nuclear layer degeneration ( J:348234 )

• progressive loss of the outer nuclear layer so by 4 months only one layer of cells remain

retina degeneration ( J:348234 )

• retinal degeneration with sclerotic retinal vessels at 4 weeks of age

abnormal eye electrophysiology ( J:348234 )

• abnormal electroretinogram responses degrade to no electroretinogram responses by 4 weeks of age

cardiovascular system

abnormal retina blood vessel morphology ( J:348234 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cone-rod dystrophy 2		DOID:0111005	OMIM:120970	J:348234
Leber congenital amaurosis 7		DOID:0110333	OMIM:613829	J:348234