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Phenotypes Associated with This Genotype
Genotype
MGI:7640235
cx3
Allelic
Composition		 Eogttm1.2Okaj/Eogttm1.2Okaj
Notch1tm2.1Pst/Notch1+
Genetic
Background		 involves: 129/Sv * C57BL/6J * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eogttm1.2Okaj mutation (0 available); any Eogt mutation (44 available)
Notch1tm2.1Pst mutation (0 available); any Notch1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal retina vasculature morphology ( J:254752 )
• retinal vascular defects are enhanced in P5 and P15 mice compared to either single homozygote, with even greater vessel branching and number of filopodia

vision/eye
abnormal retina vasculature morphology ( J:254752 )
• retinal vascular defects are enhanced in P5 and P15 mice compared to either single homozygote, with even greater vessel branching and number of filopodia

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory