Phenotypes Associated with This Genotype

Genotype
MGI:7645771

• Allelic Composition: Dph1^em1Swei/Dph1^em2Swei
• Genetic Background: C57BL/6J-Dph1^em1Swei Dph1^em2Swei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

short Meckel's cartilage ( J:347602 )

• in embryos

small mandible ( J:347602 )

• in embryos

palatal shelves fail to meet at midline ( J:347602 )

• palatal shelves extend downwards in E14.5 embryos

• palatal shelves not fused in E15.5 embryos

digestive/alimentary system

palatal shelves fail to meet at midline ( J:347602 )

• palatal shelves extend downwards in E14.5 embryos

• palatal shelves not fused in E15.5 embryos

embryo

decreased embryo size ( J:347602 )

• from stage E10.5

growth/size/body

palatal shelves fail to meet at midline ( J:347602 )

• palatal shelves extend downwards in E14.5 embryos

• palatal shelves not fused in E15.5 embryos

decreased embryo size ( J:347602 )

• from stage E10.5

mortality/aging

prenatal lethality, complete penetrance ( J:347602 )

skeleton

short Meckel's cartilage ( J:347602 )

• in embryos

small mandible ( J:347602 )

• in embryos

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
diphthamide deficiency syndrome 1		DOID:0070477	OMIM:616901	J:347602