growth/size/body
• mice are significantly smaller than controls at P7
|
• mice are born with normal body weight but develop a postnatal growth retardation
|
integument
• tail skin shows markedly reduced sebaceous glands by 8 months of age
• adult footpad skin shows diminished sebaceous glands
|
• adult foot pad skin shows strongly reduced eccrine sweat gland numbers
|
anhidrosis
(
J:344153
)
• mice exhibit anhidrosis
|
• mice show structural hair abnormalities
|
• mice exhibit a delay in hair growth at P7
|
sparse hair
(
J:344153
)
• at P21, mice have a sparser fur coat and patches with reduced hair on the upper back
• adult mice show a generalized sparseness of the fur coat by 8 months of age
• however, no aplasia cutis congenita (ACC)-like lesions are observed
|
• at 3 weeks of age, back skin shows structural hair shaft abnormalities
• at 8 months of age, tail skin shows abnormal hairs
|
• at P4, skin shows abnormal and shorter hair follicles
• at 3 weeks of age, tail skin shows hair follicles with flattened scale/interscale junctions
|
• at P4, skin shows shorter hair follicles
|
• mice show abnormal whisker hair follicles
|
• at P4 and P13, mice exhibit curly whiskers
|
• mice exhibit a delay in skin maturation
|
limbs/digits/tail
• adult foot pad skin shows strongly reduced eccrine sweat gland numbers
|
• at P4, mice exhibit a delay in interdigital web space formation
|
vision/eye
• at P13, mice exhibit a delay in eyelid opening
|
endocrine/exocrine glands
• tail skin shows markedly reduced sebaceous glands by 8 months of age
• adult footpad skin shows diminished sebaceous glands
|
• adult foot pad skin shows strongly reduced eccrine sweat gland numbers
|
anhidrosis
(
J:344153
)
• mice exhibit anhidrosis
|
craniofacial
N |
• mice exhibit normal incisor formation
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
scalp-ear-nipple syndrome | DOID:0111550 |
OMIM:181270 |
J:344153 |