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Phenotypes Associated with This Genotype
Genotype
MGI:7657832
Allelic
Composition
Kctd1tm1c(EUCOMM)Wtsi/Kctd1tm1c(EUCOMM)Wtsi
Kctd15tm1c(EUCOMM)Wtsi/Kctd15tm1c(EUCOMM)Wtsi
Tg(KRT14-cre)1Amc/0
Genetic
Background
involves: C57BL/6N * C57BL/6NJ
Cell Lines EPD0177_1_E09
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kctd15tm1c(EUCOMM)Wtsi mutation (0 available); any Kctd15 mutation (26 available)
Kctd1tm1c(EUCOMM)Wtsi mutation (0 available); any Kctd1 mutation (39 available)
Tg(KRT14-cre)1Amc mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice are significantly smaller than controls at P7
• mice are born with normal body weight but develop a postnatal growth retardation

integument
• tail skin shows markedly reduced sebaceous glands by 8 months of age
• adult footpad skin shows diminished sebaceous glands
• adult foot pad skin shows strongly reduced eccrine sweat gland numbers
• mice exhibit anhidrosis
• mice show structural hair abnormalities
• mice exhibit a delay in hair growth at P7
• at P21, mice have a sparser fur coat and patches with reduced hair on the upper back
• adult mice show a generalized sparseness of the fur coat by 8 months of age
• however, no aplasia cutis congenita (ACC)-like lesions are observed
• at 3 weeks of age, back skin shows structural hair shaft abnormalities
• at 8 months of age, tail skin shows abnormal hairs
• at P4, skin shows abnormal and shorter hair follicles
• at 3 weeks of age, tail skin shows hair follicles with flattened scale/interscale junctions
• at P4, skin shows shorter hair follicles
• mice show abnormal whisker hair follicles
• at P4 and P13, mice exhibit curly whiskers
• at P4, skin thickness is significantly reduced relative to controls
• mice exhibit a delay in skin maturation

limbs/digits/tail
• adult foot pad skin shows strongly reduced eccrine sweat gland numbers
• at P4, mice exhibit a delay in interdigital web space formation

vision/eye
• at P13, mice exhibit a delay in eyelid opening

endocrine/exocrine glands
• tail skin shows markedly reduced sebaceous glands by 8 months of age
• adult footpad skin shows diminished sebaceous glands
• adult foot pad skin shows strongly reduced eccrine sweat gland numbers
• mice exhibit anhidrosis

craniofacial
N
• mice exhibit normal incisor formation

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
scalp-ear-nipple syndrome DOID:0111550 OMIM:181270
J:344153


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory