Analysis Tools
growth/size/body
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• weight does not reach control levels at 40-50 days and 60-75 days
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• by day 44, mice develop enlarged spleen
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endocrine/exocrine glands
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• by day 44, thymus has reduced cellularity
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immune system
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• both CD8+ and CD4+ T cells show a reduced capacity to expand in response to CD3/CD28 stimulation
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• by day 44, thymus has reduced cellularity
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• by day 44, mice develop enlarged spleen
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• mice exhibit a deficiency in T regulatory cells (CD4+, CD25+, FoxP3+)
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• mice show prevention of the fatal systemic autoimmune and inflammatory disease that is seen in Foxp3sf/Y mice, with mice surviving at least up to 80 days and no presentation of scaly tails and ears, and no inflammation and tissue disruption at day 44
• values of total T cells return to normal and the accumulation of effector memory CD4+ and CD8+ T cells in the spleen that is seen in single Foxp3
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hematopoietic system
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• both CD8+ and CD4+ T cells show a reduced capacity to expand in response to CD3/CD28 stimulation
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• by day 44, thymus has reduced cellularity
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• by day 44, mice develop enlarged spleen
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• mice exhibit a deficiency in T regulatory cells (CD4+, CD25+, FoxP3+)
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cellular
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• both CD8+ and CD4+ T cells show a reduced capacity to expand in response to CD3/CD28 stimulation
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