Phenotypes Associated with This Genotype

Genotype
MGI:7664100

cx14

• Allelic Composition: Ins2^Akita/Ins2⁺; Or12d17^em1Cya/Or12d17^em1Cya
• Genetic Background: C57BL/6-Ins2^Akita Or12d17^em1Cya

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:321591 )

N • islets show increased expression of pancreatic beta cell markers in islets than that seen in Ins2^Akita mice, indicating rescue of the reduced pancreatic beta cells in islets

abnormal pancreatic islet morphology ( J:321591 )

• mice show partial rescue of the decreased insulin content in islets seen in Ins2^Akita mice but insulin content is still lower than in wild-type mice

• mice show partial rescue of the increased CD11c+ macrophages in islets of Ins2^Akita mice

growth/size/body

growth/size/body region phenotype ( J:321591 )

N • mice show rescue of the decreased body weight seen in heterozygous Ins2^Akita mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:321591 )

N • mice show reversal of the increased energy expenditure and reduced respiratory quotient seen in the dark photo-period of heterozygous Ins2^Akita mice

decreased circulating insulin level ( J:321591 )

• mice show improved glucose-induced plasma insulin levels at 8 weeks of age compared to heterozygous Ins2^Akita mice but not fully to wild-type levels

impaired glucose tolerance ( J:321591 )

• mice show markedly improved glucose tolerance at 8 weeks of age compared to heterozygous Ins2^Akita mice but not fully to wild-type levels