Phenotypes for Ccdc159 MGI:7703517 MGI Mouse

reproductive system phenotype ( J:351297 )

N	• no gross abnormalities in testes size or weight

abnormal spermatogenesis ( J:351297 )

• in the base membrane of stages VIIVIII seminiferous tubules and at stage IX there are unreleased sperm heads arranged along the lumen

abnormal sperm flagellum morphology ( J:351297 )

• abnormally folded

abnormal sperm axoneme morphology ( J:351297 )

• abnormal axonal microtubules which appear in 11 + 2 or 5+ 2 structures

abnormal sperm connecting piece morphology ( J:351297 )

• increased space between the nuclear and inner acrosomal membranes as well as the cytoplasmic membrane

• an intact connecting piece is not observed with the capitulum and segmented columns are only partially formed or absent

• the nine triclinic microtubules of the proximal centrioles are incomplete or irregular

abnormal sperm mitochondrial sheath morphology ( J:351297 )

• folding and swelling of the mitochondrial sheath

• sheaths are partially formed or abnormally stacked

disorganized sperm mitochondrial sheath ( J:351297 )

• in headless tails

• incomplete and irregularly arranged ODFs and axonemal microtubules

absent sperm fibrous sheath ( J:351297 )

detached sperm flagellum ( J:351297 )

• spermatozoa released from the caput, corpus, and cauda epididymis are exclusively headless tails and tailless heads

• head-tail detachment occurs before the release into the epididymis

• both the heads and tails are separately wrapped with intact plasma membranes indicating that separation occurs before sperm maturation

abnormal acrosome morphology ( J:351297 )

• abnormally swollen

abnormal spermatid morphology ( J:351297 )

• increased numbers of round and elongated spermatids in the stage IV - VI seminiferous tubules

• increase in the number of elongated spermatids in stage IX seminiferous tubules due to spermatids not being released and remaining in the lumen of the tubule

male infertility ( J:351297 )

• males but not females, are infertile