Phenotypes Associated with This Genotype

Genotype
MGI:7703667

• Allelic Composition: Fam210b^em1Cya/Fam210b^em1Cya
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged spleen ( J:351618 )

• at 12 weeks of age in 15.68% of mice

increased splenocyte number ( J:351618 )

• increase in the proportion of CD71+ erythroid cells in the spleen of diseased mice

increased IgG level ( J:351618 )

• IgG deposits in the glomeruli and damaged skins

abnormal splenocyte physiology ( J:351618 )

• CD71+ erythroid cells in the spleen produce elevated reactive oxygen species

• co-culture of CD71+ erythroid cells and lymphocytes results in increased levels of double strand DNA and IgG in the supernatant suggesting that the erythroid cells lead to activation of lymphocytes

increased anti-nuclear antigen antibody level ( J:351618 )

• increased 2.38 fold

increased anti-double stranded DNA antibody level ( J:351618 )

• increased 3.91 fold

glomerulonephritis ( J:351618 )

• with mesangial hyperplasia

integument

skin lesions ( J:351618 )

• with sebaceous hyperplasia and massive lymphocyte infiltration

spontaneous skin ulceration ( J:351618 )

• at 12 weeks of age in 15.68% of mice

hematopoietic system

enlarged spleen ( J:351618 )

• at 12 weeks of age in 15.68% of mice

abnormal erythropoiesis ( J:351618 )

• increase in the proportion of CD71+Ter119- and CD71+Ter119+ cells in the spleen at 20 weeks of age compared to controls indicating a inhibition in the differentiation and development of erythroid cells

increased splenocyte number ( J:351618 )

• increase in the proportion of CD71+ erythroid cells in the spleen of diseased mice

increased IgG level ( J:351618 )

• IgG deposits in the glomeruli and damaged skins

abnormal splenocyte physiology ( J:351618 )

• CD71+ erythroid cells in the spleen produce elevated reactive oxygen species

• co-culture of CD71+ erythroid cells and lymphocytes results in increased levels of double strand DNA and IgG in the supernatant suggesting that the erythroid cells lead to activation of lymphocytes

renal/urinary system

glomerulonephritis ( J:351618 )

• with mesangial hyperplasia

growth/size/body

enlarged spleen ( J:351618 )

• at 12 weeks of age in 15.68% of mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:351618