Analysis Tools
growth/size/body
microcephaly
(
J:353384
)
 |
|
|
|
• decrease in nose-to-tail length
|
adipose tissue
craniofacial
|
|
• mice exhibit rounder skull
• 72.2% of linear distances are shortened between 2 and 7% in the skull
|
|
|
• reduction in skull length, while skull width is normal
• along the rostro-caudal axis of the skull, 25.6% of distances are reduced, suggesting mild shortening and deformation of the skull
|
endocrine/exocrine glands
homeostasis/metabolism
|
|
• mice show altered O-GlcNAcylation homeostasis with decreased global O-GlcNAcylation and reduced O-GlcNAcase and O-GlcNAc transferase protein levels in the brain
|
|
|
• mice show lower levels of glycemia
|
nervous system
|
|
• decrease in absolute brain weight
|
skeleton
|
|
• mice exhibit rounder skull
• 72.2% of linear distances are shortened between 2 and 7% in the skull
|
|
|
• reduction in skull length, while skull width is normal
• along the rostro-caudal axis of the skull, 25.6% of distances are reduced, suggesting mild shortening and deformation of the skull
|
mortality/aging
|
N |
• mice are viable
|
reproductive system
|
N |
• normal fertility
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| congenital disorder of glycosylation | DOID:5212 | J:353384 | ||
