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Phenotypes Associated with This Genotype
Genotype
MGI:7716953
cx4
Allelic
Composition		 Miga2tm1a(KOMP)Wtsi/Miga2tm1a(KOMP)Wtsi
Pnp2em1Smoc/Pnp2em1Smoc
Genetic
Background		 C57BL/6-Miga2tm1a(KOMP)Wtsi Pnp2em1Smoc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Miga2tm1a(KOMP)Wtsi mutation (2 available); any Miga2 mutation (36 available)
Pnp2em1Smoc mutation (1 available); any Pnp2 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal CD4-positive, alpha-beta T cell physiology ( J:339075 )
• CD4+ T cells grown in culture show partial normalization of the hyperproduction of xanthine that is seen in single Miga2tm1a(KOMP)Wtsi homozygotes but still greater than in wild-type mice

immune system
abnormal CD4-positive, alpha-beta T cell physiology ( J:339075 )
• CD4+ T cells grown in culture show partial normalization of the hyperproduction of xanthine that is seen in single Miga2tm1a(KOMP)Wtsi homozygotes but still greater than in wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory