Phenotypes Associated with This Genotype

Genotype
MGI:7718590

• Allelic Composition: Car1^tm1.1Nju/Car1^tm1.1Nju
• Genetic Background: involves: C57BL/6J * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased depression-related behavior ( J:336771 )

• mice exhibit increased immobility time in the forced swimming test and in the tail suspension test indicating depression-like behavior

• however, no difference is seen in sucrose preference

increased anxiety-related response ( J:336771 )

• mice show decreased time and distances traveled in the open arms of the elevated plus maze and increased time in the closed arms, indicating increased anxiety

• however, no difference is seen in the total moving distances in the open field test

nervous system

abnormal hippocampus CA4 region morphology ( J:336771 )

• mice exhibit decreased concentrations of bicarbonate and proton levels (increased pH) in the extracellular space of the hippocampal hilus

abnormal synaptic physiology ( J:336771 )

• granule cells in the dentate gyrus show increased evoked responses to the perforant pathway stimulation, indicating that the excitability of granule cells is increased

enhanced long-term potentiation ( J:336771 )

• long-term potentiation of the Schaffer collateral pathway (CA3-CA1) downstream of the dentate gyrus is enhanced

decreased miniature inhibitory postsynaptic current amplitude ( J:336771 )

• the amplitude of mIPSC of granule cells in the hippocampal dentate gyrus is decreased

• however, no changes in either amplitude or frequency of miniature EPSC in the hippocampus and neither mEPSC nor mIPSC of pyramidal cells in CA1 is altered

• mice show no change in current ratio of AMPAR/NMDAR or NMDAR2a/NMDAR2B, indicating unaffected glutamatergic synaptic transmission

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
major depressive disorder		DOID:1470	OMIM:608520 OMIM:608691	J:336771