Phenotypes for Diras2 Kras Ptf1a Ube2f MGI:7738284 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Diras2^em1Gpt/Diras2^em1Gpt Kras^tm4Tyj/Kras⁺ Ptf1a^tm1(cre)Hnak/Ptf1a⁺ Ube2f^{tm1c(EUCOMM)Hmgu}/Ube2f^{tm1c(EUCOMM)Hmgu}
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Diras2^em1Gpt mutation (0 available); any Diras2 mutation (20 available)
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Ptf1a^tm1(cre)Hnak mutation (1 available); any Ptf1a mutation (31 available)
Ube2f^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Ube2f mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreas tumor incidence ( J:348744 )

• relative to mutant mice wild-type for Diras2

• incidence of pancreatic tumors is similar to mutant mice wild-type for both Diras2 and Ube2f but with fewer stage I and more stage II and III tumors

neoplasm

increased pancreas tumor incidence ( J:348744 )

• relative to mutant mice wild-type for Diras2

• incidence of pancreatic tumors is similar to mutant mice wild-type for both Diras2 and Ube2f but with fewer stage I and more stage II and III tumors

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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