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Phenotypes Associated with This Genotype
Genotype
MGI:7764754
hm2
Allelic
Composition
Il6tm1Kopf/Il6tm1Kopf
Genetic
Background
C.129S2(B6)-Il6tm1Kopf
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation (9 available); any Il6 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• nearly 80% of specific-pathogen free (SPF) mutant mice infected with Rauscher-like murine leukemia virus (RL-MuLV) exhibit leukemia by 150 days compared to 50% of SPF wild-type mice
• however, development of leukemia after infection with RL-MuLV occurs at the same latency and with similar incidence as in wild-type mice


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory