Phenotypes Associated with This Genotype

Genotype
MGI:7782632

hm1

• Allelic Composition: Mir497^em1Hgyu/Mir497^em1Hgyu
• Genetic Background: C57BL/6-Mir497^em1Hgyu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

increased susceptibility to induced colitis ( J:357958 )

• mice exhibit an increase in the severity of dextran sodium sulfate (DSS)-induced colitis from the 5th day, showing earlier weight loss, more pronounced weight loss, earlier onset of diarrhea and fecal blood, enhanced inflammatory response with more severe inflammatory cell infiltration, increased pro-inflammatory factor and chemokine expression and crypt damage, more significant increase in colon weight/length ratio, colon shortening, spleen weight, and reduced liver weight

immune system

increased susceptibility to induced colitis ( J:357958 )

• mice exhibit an increase in the severity of dextran sodium sulfate (DSS)-induced colitis from the 5th day, showing earlier weight loss, more pronounced weight loss, earlier onset of diarrhea and fecal blood, enhanced inflammatory response with more severe inflammatory cell infiltration, increased pro-inflammatory factor and chemokine expression and crypt damage, more significant increase in colon weight/length ratio, colon shortening, spleen weight, and reduced liver weight