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Phenotypes Associated with This Genotype
Genotype
MGI:7783467
cx3
Allelic
Composition		 Ttll1tm1Seto/Ttll1+
Ttll7tm1Seto/Ttll7tm1Seto
Genetic
Background		 involves: 129 * 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttll1tm1Seto mutation (1 available); any Ttll1 mutation (39 available)
Ttll7tm1Seto mutation (1 available); any Ttll7 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:345300 )
• following continuous i.p. injection of pilocarpine hydrochloride to induce kindling, mice show a significantly longer duration of obvious epilepsy-like symptoms (highest score) than wild-type controls over 135 min of observation

nervous system
increased susceptibility to pharmacologically induced seizures ( J:345300 )
• following continuous i.p. injection of pilocarpine hydrochloride to induce kindling, mice show a significantly longer duration of obvious epilepsy-like symptoms (highest score) than wild-type controls over 135 min of observation

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory