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Phenotypes Associated with This Genotype
Genotype
MGI:7786713
hm9
Allelic
Composition
Leprdb/Leprdb
Genetic
Background
BKS(D)-Leprdb/JOrlRj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Leprdb mutation (17 available); any Lepr mutation (125 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• male mice are obese at 10-11 weeks of age
• male mice fed a standard diet gain significantly more weight than heterozygous littermates between 5 and 11 weeks of age

homeostasis/metabolism
• at 10-11 weeks of age, male mice show significantly higher plasma levels of 3-deoxyglucosone, methylglyoxal, and dimethylglyoxal than heterozygous littermates
• however, plasma glyoxal levels are normal
• male mice are hyperglycemic at 10-11 weeks of age


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/17/2024
MGI 6.24
The Jackson Laboratory