Phenotypes Associated with This Genotype

Genotype
MGI:7786760

ht2

• Allelic Composition: Atp13a3^em2H/Atp13a3⁺
• Genetic Background: C57BL/6NTac-Atp13a3^em2H/H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal pulmonary artery morphology ( J:358006 )

♂ • lung vascular morphometric analysis shows higher percentage of fully muscularized small pulmonary arteries

abnormal myocardial fiber morphology ( J:358006 )

♂ • increase in cardiomyocyte cross-sectional diameter

heart right ventricle hypertrophy ( J:358006 )

♂

cardiac interstitial fibrosis ( J:358006 )

♂

abnormal heart echocardiography feature ( J:358006 )

♂ • mice exhibit increased right heart dimensions, namely right ventricular inner diameter and right ventricular end-diastolic anterior wall thickness

♂ • however, heart rate and systemic blood pressure do not differ in 6 months old males

increased pulmonary artery pressure ( J:358006 )

♂ • transthoracic echocardiography shows a shortening of pulmonary acceleration time (a surrogate of pulmonary artery pressure and pulmonary vascular resistance)

pulmonary hypertension ( J:358006 )

♂ • males spontaneously and consistently develop pulmonary hypertension at 6 months, but not 3 months, of age, with a significantly elevation of right ventricular systolic pressure

♂ • females exhibit normal pressures at 6 months

cellular

cardiac interstitial fibrosis ( J:358006 )

♂

growth/size/body

heart right ventricle hypertrophy ( J:358006 )

♂

muscle

abnormal myocardial fiber morphology ( J:358006 )

♂ • increase in cardiomyocyte cross-sectional diameter

heart right ventricle hypertrophy ( J:358006 )

♂